Showing posts with label health-fitness. Show all posts
Showing posts with label health-fitness. Show all posts
Monday, April 11, 2011

Test Your Telomere Length... Now!

    11 April 2011

    I've been following the scientific study of telomere length since reading Matt Ridley's classic popular science work: "Genome."

    To cite a recent online article in Scientific American:

    "Telomeres are caps on the ends of chromosomes, protecting them much as plastic tips on the ends of shoelaces keep the laces from fraying. Whenever chromosomes—the store­houses of our genes—are replicated in preparation for cell division, their telomeres shorten. That shrinking has led many scientists to view telomere length as a marker of biological aging, a “molecular” clock ticking off the cell’s life span, as well as an indicator of overall health.

    "Studies comparing the telomere length of white blood cells among groups of volunteers show distinct correlations between telomere length and lifestyle. Those who exercise regularly have longer telomeres than those who do not. Folks who perceive themselves as the most stressed have shorter telomeres than those who see themselves as the least. Certain diseases, too, correlate with shorter telomeres, including cardiovascular (illness), obesity and Alzheimer’s."

    Well, the long and the short of it - in this case, in fact the critical factor - is that it is now possible to get your telomere length tested.

    Scientific American is not a "commercial" publication, so they did not provide the link to the company that plans to offer this service, but here they are: "Life Length."

    Contacts for the company are as follows:

    Stephen Matlin
    smatlin@lifelength.com

    Nuño Arroyo
    narroyo@lifelength.com

    Marisol Quintero
    mquintero@lifelength.com

    I have already e-mailed Mr. Matlin, and he indicates that the test is presently available at a cost of €500.

    His contact information is as follows:

    Stephen J.Matlin

    Chief Executive Officer




    Agustín de Betancourt, 21 – 8th floor

    Madrid, Spain 28003

    T +(34) 91 395 6368

    M +(34) 629 343 694

    www.lifelength.com

    I'll let you know exactly what's up as I find out more.

    Again, telomere length is one of the critical factors in aging.

    Though we're a long way from being able to modify telomere length in individual humans, another company (Geron Corp.) is working on doing exactly this. Their present focus is on the use of telomerase blocking to control the proliferation of cancer cells.

    From Geron's website:

    "We and others have shown that when the enzyme telomerase is introduced into normal cells, it can restore telomere length - reset the "clock" - thereby increasing the functional lifespan of the cells. Importantly, it does this without altering the cells' biology or causing them to become cancerous.

    "Human telomerase, a complex enzyme, is composed of a ribonucleic acid (RNA) component, known as hTR, a protein component, known as hTERT, and other accessory proteins. In 1994, we cloned the gene for hTR, and in 1997, with collaborators, cloned the gene for hTERT.

    "The 2009 Nobel Prize for Physiology and Medicine was awarded for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.

    "The Nobel laureates were early Geron collaborators, Elizabeth H. Blackburn and Carol W. Greider, along with Jack W. Szostak."

    Without further ado, let's start by checking out our telomere length with the help of the folks at Life Length.

    Then we'll take it from there.

    For other advances in genetic testing, please visit my earlier post on the (now private) genomics pioneer, deCODE Genetics (also featured in Ridley's book).
    _Source URL: https://idontwanttobeanythingotherthanme.blogspot.com/search/label/health-fitness
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Tuesday, April 21, 2009

Rescue deCODE Genetics, not GM!

    21 April 2009

    I have posted previously about the landmark work that deCODE Genetics is carrying out in Iceland.

    Unfortunately, this trailblazing company has overextended itself by taking on far-reaching research projects based on the analysis of genetic factors linked to the development of a wide range of human diseases.

    deCODE announced on March 31, 2009 that it has run out of funds, is probably no longer a "going concern," and that it will now be divesting its various business units if possible.

    Let me make a simple point.

    deCODE Genetics is carrying out work that will benefit all of humanity for millennia to come.

    General Motors has overextended itself by paying premium salaries to its employees and offering excessive bonuses and other perks to its executives and managers for decades, leading it into an unsustainable business situation.

    deCODE Genetics and General Motors are thus in similar circumstances.

    However, here is the difference. deCODE Genetics overextended itself doing work that will potentially aid every human being on this planet.

    General Motors overextended itself by diverting its revenues to its executives and frontline workers at the expense of operating a profitable business for the benefit of its shareholders.

    Rescuing deCODE Genetics would provide lasting benefits to every one of us and all of our descendants.

    Rescuing GM will preserve a corporate dinosaur with a legacy of decades of horrible business practices.

    I'm serious, let's reorganize the multi-trillion dollar financial rescue programs now being advanced by every Western government and fund the continuing operations of deCODE Genetics - thereby permitting GM to bear the natural consequences of its lengthy and well-documented history of mismanagement.

    Somebody else will manufacture the cars and trucks we need if the inefficient automakers are let go.

    By way of contrast, if deCODE Genetics goes out of business, important work to promote human health and wellbeing will be delayed for years if not decades to come.

    Our priorities are simply wrong.

    Here's a desperate suggestion to save deCODE, as no politician in any party is likely to adopt the rational course of action that I am proposing.

    Let's set deCODE Genetics up as a registered international charitable foundation. I for one would contribute voluntarily to preserve and promote the work of this wonderful company. deCODE Genetics stands head and shoulders above General Motors by every standard that I can think of. I would rescue this company personally if I only had the means to do so! I wish a few more politicians thought in the same way that I do....

    In the interim, I urge those who are interested to consider taking advantage of the innovative "deCODE Me" personal genome scan service now being offered by this company. Believe me, science fiction has now come to life, and the deCODE team are perhaps the leading pioneers in the visionary and critically important field of personal genetic analysis!

    (On a side note - I received a personal notice from deCODE today that they have received the personal genetic samples necessary to begin my personal Cardio Scan. I'll be receiving my results very soon!)
    _Source URL: https://idontwanttobeanythingotherthanme.blogspot.com/search/label/health-fitness
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Tuesday, February 3, 2009

deCODEme - The Era of Genetic Medicine is Here

Wednesday, November 19, 2008

Upcoming Blog Topics

    10 November 2008, updated 20 November 2008

    Sorry!

    I've been too busy to blog. I'm getting ready for a seven-week working holiday, and have had no free time at all. We start out on the road to Scottsdale in the near future, and I'll be blogging again once I settle in.

    Topics that are at least mentally in the works include:

    (1) The market is a blind, charging beast.

    Along with fellow precious metal investors, I saw the recent market collapse coming years ago. I invested in precious metal mining and exploration stocks because they are NOT correlated with the general market. Here's what I didn't allow for... the precious metal miners have performed worse than the broad market, and the precious metal exploration companies have fared far worse - they are trading as though they are going out of business! I was right that my investments wouldn't be correlated, but it was not in the direction I expected. Are precious metal miners and explorers therefore the wrong place to be? I don't think so, though so far, the market obviously doesn't agree with me. As it happens, I also don't agree with the market. More later.... perhaps much more!


    (2) The US election - Mr. Obama catches a sack of hot potatoes.

    President-elect Obama has a hard job. He also has a bad economic plan (attack the rich to aid the poor - it doesn't work), though 20 advisers are apparently guiding his actions. Hopefully they're smart, because George Bush's job looks easy compared to the debt-laced lemonade that the spendthrift Republican administration is handing over to Mr. Obama! Personally, I have had all I can take of the Republicans' paranoid, "interest-based" international politics, as well as of their intrusions into their citizens' private lives, both of which have grown totally out of hand. So, I'm holding my nose and wishing Mr. Obama well. He'll need all the good wishes he can get, but at least he is acknowledging the complexity and diversity of human nature, and of the US melting pot of the 21st century.

    (3) What do you love?

    The answer, for me... is stories, and art as the context of the story, if you will. I raised this topic on September 12, 2007, and I now plan to get back to it!

    (4) Ephemeralization... How to do more with less in the 21st century.

    Hats off to Buckminster Fuller. The challenge of our age is obviously about how to do more with less. Let's get a little more serious about that!

    (5) Healthy living.

    What are the core constituents of a healthy lifestyle? My latest thoughts, with an acknowledgement to Chris Crowley, Henry Lodge and Ray Kurzweil.

    (6) Ghomeshi - moving beyond Gzowski to take us into the 21st century.

    Jian Ghomeshi, presently of CBC Radio Q (now playing in the mornings at 10:00 a.m.), has taken on the mantle of Peter Gzowski, and worn it well. He is Canada's foremost radio personality, and well-equipped to lead the broadcaster into the new millennium. A tribute to the genius of Ghomeshi.

    For now, I'll just be posting concepts for future entries.


    I'll have time to post the full content at some point after arriving in Arizona next week!

    November 20, 2008:

    Here are two more topics coming up....

    (7) "Thirty Reasons for Great Depression Two by 2011." Here I am referring to Paul Farrell's can't miss editorial on Marketwatch. Click the link until I can say more about this!

    (8) We Are All Millionaires - A Parable. Here I want to reflect on the fact that every one of us is rich beyond words in unimaginable gifts. I also intend to argue that almost every one of us has an area of intellectual specialization that endows us with unique genius. More coming on this topic for sure!
    _
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Monday, May 12, 2008

The Kenora Palette in May

    12 May 2008

    I tend to become discontented with Kenora, my home community of the past 16 years, due to its long and severe winters and its correspondingly brief and sometimes chilly summers. Therefore, I have assigned myself the task of noticing what is beautiful about where I live.

    This has proven a very powerful experiment, as for the first time following our month's visit to Southern California in April, I actually looked forward to coming home. This delightful anticipation was not shaken despite being snowed-in in Winnipeg upon arrival due to a severe spring blizzard's having overwhelmed the TransCanada Highway, resulting in its closure for 24 hours.

    There are no alternative roads to Kenora, so we relaxed in Winnipeg for an extra day, and enjoyed Martin Scorsese's excellent Rolling Stones documentary at Imax: Shine a Light. Scorsese was so adept in capturing the subtleties of the performance that I think I would choose watching this on Imax over being there live. Yes, it was that well done by Scorsese, and the Imax effect was awe-inspiring, as always!

    Well, it is now my wish to shine a light on Kenora's stark and still subtle May palette. In contrast to my March 2008 post (The Kenora March Palette), please note that the present snapshots include brighter greens against a still somber background, signalling the incipient arrival of Spring.

    Spring always comes almost instantly here, then to be followed by summer, sometimes only two weeks later!

    I'll also include an image of Susan bouldering, as this was her activity of the day on May 11, 2008.

    Be sure to click on the images for larger versions!

    Notice how the uncluttered expanse of blue sky gives richness to the understated tones of the Canadian Shield: granite rock, boreal forest and damp meadow.

    It remains my plan to figure out how we can bring every one of these colours into our home, so that we are living with them year-round both indoors and out.

    The Kenora palette series:

    The Kenora March Palette: 2009

    The Kenora Palette: After the June Rain

    The Kenora May Palette Erupts into Green Tones, but also into Unexpected Hues

    The Kenora Palette in May

    The Kenora March Palette
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Monday, March 31, 2008

The Principles of Tribal Fitness: The Rhythm of the Hunt

    31 March 2008, 20 April 2008

    I am the archetypal civilized as opposed to tribal person. I am an aficionado of the highest achievements of human culture and civilization, from the great works of art to the accomplishments of music, architecture, drama and literature. While I am hardly the world's most cultured person (you may wish to visit the Juilliard School or the Banff School of Fine Arts to obtain a much greater dose of culture than I can personally convey to you), I am definitely at the civilized as opposed to the tribal end of the human cultural spectrum.

    Be that as it may, I am going to spend the balance of this article advocating for a particular aspect of tribal human behaviour.

    Why?

    Because our survival - as individuals - depends upon mastering the principles of tribal fitness.

    If we learn these principles, we stand to live well into the last decades of our lives (no matter how long or short the span that our own genetic program, habitual behaviours and environmental circumstances may actually allow us).

    I have referred in an earlier entry to the groundbreaking text on fitness after 50, Younger Next Year. The phrase "rhythm of the hunt" came to me through an entry of Dr. Henry (Harry) Lodge on the Younger Next Year Website.

    Dr. Lodge's entry is so well-written, I am tempted to quote it in full here, but that should not be necessary, as you can go directly to the source yourself.

    What is Dr. Lodge suggesting?

    In essence, humans have lived as tribal beings for over 99% of our two million years of evolution. This simple fact means that very little meaningful biological evolutionary development has occurred during our 7000 years at most of civilized life.

    While culturally and psychologically, we may be very civilized beings, biologically, we are tribal beings, and that is simply a fact.

    How then did we evolve - biologically - as tribal peoples?

    In one term - as hunter-gatherers.

    Again, no more than 1% of human evolution has been characterized by the three developmental stages subsequent to the hunter-gatherer lifestyle (horticultural/pastoral; chiefdom; civil society).

    How do hunter-gatherers live?

    Again, the brief answer is "from the gifts of the land." From a civilized perspective, that may seem a difficult lifestyle, but it was obviously good enough to tide our ancestors through 2 million years of evolutionary history.

    For hunter/gatherers, sometimes the land gave, and sometimes it did not.

    Going beyond Dr. Lodge, I would speculatively characterize the tribal (hunter/gatherer) lifestyle as involving three phases - linked to three types of activity.

    Phase I is gathering the fruits of the land. The activity associated with gathering was probably many hours of walking, bending, stooping, digging, collecting, and intermittently resting, per day. While gathering implies a vegetarian component to our diet, this was not strictly a vegetarian activity, as many animal sources of nutrition are also susceptible to gathering, including the collection of shellfish, the gathering of eggs, and probably catching fish in many cases as well.

    Phase I is characterized by a gentle sustained pace of exercise mostly equivalent to walking or jogging as an exercise form.

    Phase II is hunting, and to the best of our knowledge, based on the study of contemporary hunter/gatherer societies, this was characteristically a group activity, and was accompanied by a number of active rituals, as well as by hunting forays to bring home high protein/high fat game for the tribal group.

    Hunting involves not only vigorous running and effortful use of weapons and carrying of the kill, but also many complex and integrated bodily movements, such as twisting, striking, lifting, cutting, turning, altering direction and pace, etc.

    Phase III - not mentioned by Dr. Lodge, but also obviously relevant to the tribal lifestyle, is fasting. In pastoral societies, such as that of the traditional Hunza, fasting was an essential element of the annual calendar, extending up to 6 weeks in late winter and early spring.

    Periods of fasting are a time for conservation of energy. Notably, the scarcity of food has defined much about human biological development. Consider, for example, that our bodies' insistence upon the storage of fat is clearly an adaptation to the recurring shortage of food during our human and pre-human developmental history. When we diet, our bodies move into food scarcity mode, and increase the rate at which they store fat, frustrating the intentions of many would-be dieters.

    Consider also that depressed mood is a survival mechanism in times of scarcity, as depressed individuals conserved energy, while active individuals risked wasting what little energy might have been stored in fat, with the result that they might not survive until the next season of plenitude.

    By way of contrast, and here I am returning to the main point of Dr. Lodge's article, hunting is an optimistic activity. The hunter, through the expenditure of great effort, increases his chances of bringing home many meals, and thereby enhancing his chances of survival, as well as the likelihood of survival of his tribal group.

    That is, biologically, the rhythm of the hunt offers some survival advantages over the rhythm of foraging.

    To begin with, the slow, steady pace of the walking gatherer is a biological strategy for burning fat, but not carbohydrates. I suspect, though I'm reading between the lines in the evidence, that psychological depression (for the reasons I offered earlier) is also linked to the foraging versus the hunting way of life.

    By way of contrast, the vigorous pace of the hunter entails the burning of the combined fuels of fat and carbohydrate, as well as to much more active use of the body as a whole - and this also appears to be linked to counterbalancing psychological processes.

    Dr. Lodge states:

    "Exercising hard enough to push yourself to the next level calls for a new fuel. You need more power than you get from fat alone, so your muscles start to burn glucose. This shift into high gear changes your metabolism, because harder exercise is the automatic signal to your body that you've started to hunt. Picture an animal when prey is in sight. His adrenaline surges, he becomes engaged and alert, his step has more bounce, he processes visual information more quickly, his reflexes sharpen, his pupils dilate. This is what happens when you turn on a whole serious of complex control mechanisms by exercising harder. When you reach this level, —starting to burn glucose—, your arms swing freely, you breathe more deeply, and your legs start to really work. You keep burning that low level of fat in the background, but all the extra fuel from this point on up is glucose.

    "Your heart rate is the only way to know for sure which metabolism is at work and which signals you're sending. Your heart delivers more and more blood to your muscles the faster it pumps, and your muscles can extract more and more fat from that blood until you reach about 65 percent of your peak heart rate. That's the limit of your first gear, and only a heart monitor can help you determine which number that is for you. As soon as you push your body a little harder, you start burning glucose in addition to fat, and you need more oxygen to do this. That means bringing more blood to the muscles so your heart rate goes up. Any heart rate above 65 percent means you're burning glucose and that you've moved into a different metabolism. You've shifted into second gear and your body starts drawing on the glucose stored in your muscles, feeding it into your mitochondria to produce extra energy.

    "Hard aerobics, working up a good sweat, is our favourite exercise rhythm because hunting brings out our youngest and best biology: strong, fast, energetic and optimistic all day long. But light aerobics builds the foundation for health better than anything else. That's why you should do light aerobic exercise a couple of days a week to build your base, and then go out and play on the hard-aerobic fields the other days."

    I have quoted Dr. Lodge at length here, because there is little that I wanted to omit, and little that could be paraphrased more concisely.

    The rhythm of the hunt, due to the efficient mitochondrial (aerobic) burning of carbohydrate fuel, engages a series of rejuvenating biological mechanisms that are not triggered by more moderate exercise.

    In my earlier essay on the ideas of Younger Next Year, I made reference to the impacts of the cytokines 6 and 10 on human health and fitness. New research since that time has revealed that both cytokine 6 (more commonly referred to as IL6) and cytokine 10 (IL10) are anti-inflammatory cell-surface signalling proteins, and that the culprit involved in the cellular breakdown associated with arthritis, diabetes and cardiovascular disease is actually another very well-characterized cytokine known as TNF (I am simplifying perhaps too much in this section, for the sake of hoped-for clarity).

    However, the fundamental idea of younger next year, and the first principle of tribal fitness, still stands.

    When we do not exercise vigorously on at least an alternating daily basis, our bodies enter fasting mode.

    Paradoxically, even when we are inactive, but flooding our bodies with calories, biologically, our bodies remain in fasting mode - because it is vigorous physical activity that signals our bodies that we are engaged in the gathering of food - not the inflow of calories!

    The body of the well-fed inactive person believes it is starving. Not only does it begin to store fat at overtime rates, it also breaks down tissue to generate energy to burn - and this is the mechanism which triggers the onset of arthritis, diabetes and cardiovascular disease, as well as probably many other diseases, possibly including some types of cancer as well.

    What about the biology of the gatherer?

    It is much healthier than the biology of the inactive person, but still problematic, at least in our contemporary context, where our closest approximation to gathering is walking. That is, the original spectrum of "lifestyle" components of traditional gathering behaviour is typically eliminated in our contemporary forms of "moderate" exercise.

    How so?

    Quite simply, our bodies do not require the peak of fitness to walk about, staying active, but at no more than an easy to moderate pace. When we walk and take in calories, our bodies know that food is available - but easily so. Thus, muscle tissue gradually dies back, and the range of our bodies' capacity for exertion becomes restricted. This is not a serious problem for younger people, but potentially a very serious problem for persons over 50, who are already facing age-related declines in physical capacity.

    That is, even regular but only mellow physical exercise permits us to come off our peak, and to function in a gradually narrower and narrower range.

    Thus, of the three "phases" of tribal fitness, only one of the three enables us to live beyond age 50 with as full as possible a range of capacities - and that is phase II - the rhythm of the hunt.

    As defined by Dr. Lodge, this means engaging our heart rate at 65% or more of maximum capacity, and engaging in strenuous (though not necessarily continuous) physical exertion (characterized in the text as "resistance training").

    On the Younger Next Year website, Dr. Lodge and his partner Chris Crowley, are beginning to define more broadly what is really entailed by the rhythm of the hunt.

    On the title page at this time is a reference to the new book, "Balance," by Scott McCredie. Mr. Crowley refers to Mr McCredie's conjecture that it may have been our human sense of balance - not our supposedly superior intelligence - that distinguished us from the Neanderthal.

    Let me go beyond Crowley and Lodge here to add a few questions or conjectures of my own.

    As I really understand the physical demands of the hunt in tribal societies (and let me hasten to add that I am a vegetarian, but my genetic code doesn't know it), there is much more demanded of our minds and bodies than our contemporary analogues of aerobic fitness, speedwork and weight training.

    That is, our "linearly" structured contemporary exercise programs constitute no more than partial approximations of the actual rhythm of the hunt that we must replicate if we are interested in arresting the progress of the degenerative processes (and diseases) that are inherent to the aging process, as well as in maximizing our physical options through maintaining peak levels of endurance, strength, flexibility and agility.

    I am beginning to think that combined aerobics and strength training, while beneficial - are simply not enough. I am not meaning to set an impossible challenge in terms of the time demands of fitness activities, but rather to be interested in thinking about how to combine activities that promote endurance, strength, balance, flexibility, agility and tolerance for variation in levels of effort.

    That is - it is not "one or the other," but how to combine as many functions into a single activity as suits our personal interests, needs, constraints and lifestyle.

    As a thought experiment, let me set out a few basic challenges, some of which I can presently pass, but some of which I cannot - and probably soon must be able to do!

    Targeting particularly my readers over 50, can you.....

    1. Complete a half marathon in any time at all?
    2. Lift (pull up) your own body's weight on a horizontal bar?
    3. Push up your own body's weight with your arms?
    4. Easily exit a chair by exerting your abdominal muscles rather than by relying on the support and strength in your arms?
    5. Comfortably assume and maintain a full squatting position (as one might witness in an Asian market)?
    6. Both sit up and stand up from a lying-down (supine) position without using your arms to push or pull?
    7. Maintain your balance while riding a bicycle or a horse over long distances?
    8. Take off, put on, tie and untie your shoes from a standing position without support?
    9. Run, turn and spin from position to position without losing your balance?
    10. Engage in at least three demanding lifestyle fitness activities (for example, team sports, individual competitive sports, distance running, rock climbing, cycle touring, skiing, roller blading, distance swimming, active dancing, etc.)?
    11. Run and keep your pace in deep snow or sand?
    12. Balance on one leg (or better still - two arms)?

    If you are 50, will you be able to do these activities when you are 70? Or if you are 60, to do them at 80, etc.?

    What kind of fitness routine do you need to accomplish your own strategy for being "younger next year?"

    There is much more I want to say, ask, and speculate about, but I will reserve these additional topics for a future article!

    20 April 2008: It is important to clarify a point that is raised by my wife Susan in her recent blog entry, "Long Walks Are Good for Your Heart x2." She is exactly right that the transition from idleness to maximum exertion is a non-natural and high-risk behavioural pattern.

    It would be more accurate to conclude not that the rhythm of the hunt is superior to the rhythm of foraging, but rather that it is a necessary and non-expendable complement to the pace of foraging. To rest and then to hunt, never engaging in foraging, seems an unlikely and unnatural life and exercise rhythm.

    The rhythm of the hunt gains its validation against the backdrop of the rhythm of foraging. Both are necessary. Seeking to capture the pace of the hunter in our exercise program, without also mastering the pace of the gatherer, is almost certainly contraindicated by the innate biological program of our hunter-gatherer bodies!

    Further, we would be wise to devote more time to mastering the rhythm of the gatherer prior to aspiring to the replication of the rhythm of the hunt. That is, let us first attain the rhythms of gathering and foraging before we seek to master the challenges of the far more demanding - and risky - rhythms of the hunt.

    It is the gatherer who is ready to engage in the mysteries and rituals of the hunt, not the sedentary individual whose body is unaccustomed to regular and habitual movement and sustained aerobic exertion.

    In the world of evolutionary (physical) fitness, we must certainly learn to walk before we can learn to run.Source URL: https://idontwanttobeanythingotherthanme.blogspot.com/search/label/health-fitness
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